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Press-Pulse Clinic

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The world's first medical retreat centre & virtual clinic dedicated to Dr Thomas Seyfried's groundbreaking Press‑Pulse Protocol A non‑toxic, mitochondrial metabolic approach to managing cancer and other chronic diseases. Grounded in peer‑reviewed science and delivered through a Canadian‑led clinic in the tranquil, healing environment of magical Tepoztlán, México. Whether you join us in person or through our interactive online program, you will receive the tools and individual support needed to master this metabolic approach to wellness. Who This Program Is For Our metabolic program supports individuals across five distinct pathways, each tailored to your diagnosis, treatment stage, and long‑term goals. 1. Neoadjuvant Therapy (Before Treatment Begins) For those diagnosed but not yet undergoing conventional treatment. This phase strengthens your metabolic resilience, preparing your body for surgery, chemotherapy, radiation, or i...
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Akkermansia and PD‑1 Response in Colorectal Cancer (CRC)

Why Akkermansia Matters in CRC Akkermansia muciniphila is a gut bacterium that lives in the mucin layer of the colon. In colorectal cancer — especially microsatellite‑stable (MSS) disease — the tumor microenvironment is typically: immunosuppressed low in interferon signaling resistant to PD‑1 inhibitors Akkermansia is emerging as a modifier of this immune resistance. 1. What the Evidence Shows in CRC A. Preclinical CRC Models In MSS CRC mouse models: Oral Akkermansia muciniphila reduced tumor growth It sensitized tumors to anti‑PD‑1 therapy Mechanisms included: TLR2 → NF‑κB activation cGAS–STING pathway activation ↑ IFN‑β ↑ CD8⁺ T‑cell infiltration This is one of the strongest mechanistic links between a gut microbe and PD‑1 responsiveness. B. Human Observational CRC Data CRC patients with higher baseline Akkermansia show: better immune activation signatures improved response patterns to PD‑1 inhibitors lower levels of immunosuppressive myeloi...
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